NEW ANTIBODY COCKTAILS
We are pleased to announce the release of the following new antibody cocktails with IVD Marking:
CD3 and CD20 cocktail (EP449E and L-26 Mouse & Rabbit Monoclonal)
CD3 is a lineage-specific “pan T-Cell” surface antigen compose of five different polypeptide chains. The CD3 antibody recognizes the human CD3 antigen which is present on mature human T cells, thymocytes, and a subset of NK cells. CD20 is a non-glycosylated phosphoprotein expressed on the surface of all mature B-cells. The CD20 antibody primarily recongnizes a 33 kD polypeptide B cell component and a monor 30 kD cellular antigen. The CD3-CD20 cocktail reveals lymphoid architecture in neoplastic situations. CD20 and CD3 antibodies are provided at optimal concentrations in an easy-touse format for visualizing T- and B-lymphocytes. This antibody cocktails can be used for the typing of malignant lymphomas and other lymphoproliferative disorders.
CD3 and CD20 cocktail (RTU Manual), 6ml, AC559-5M, cena 5.910 Kč
CD3 and CD20 cocktail (RTU Automated), 10ml, AC559-10M, cena 9.636 Kč
CD5 and CD23 Cocktail (4C7 and SP23 Mouse & Rabbit Monoclonal)
CD5, a 67-kDa glycoprotein, is generally found on the surface of T cells and is necessary for T cell activation. CD5 is also expressed on a subset of B lymphocytes. CD23 is a type II transmembrane glycoprotein that functions as a receptor for IgE. CD23 is involved in the regulation of IgE production and in the differentiation of B-cells. It is expressed in many haemopoitic cell types. CD21 has been identified as a ligand for CD23 in the control of IgE production. CD23 expression has been detected in neoplastic cells from B cell chronic lymphocyctic leukemia and in some centroblastic/centrocytic lymphoma cases. CD5 and CD23 cocktail staining is useful for the differentiation of chronic lymphocytic lymphomas and mantle cell lymphoma.
CD5 and CD23 cocktail (RTU Manual), 6ml, AC560-5M, cena 9.680 Kč
CD5 and CD23 cocktail (RTU Automated), 10ml, AC560-10M, cena 17.797 Kč
CD10 and Cyclin D1 Cocktail (56C6 and EPR2241 Mouse & Rabbit Monoclonal)
CD10, also known as common acute lymphoblastic leukemia antigen (CALLA), is a cell surface enzyme which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas and in chronic myelogenous leukemia (CML). Cyclins are a family of protein that act as key regulators of the cell cycle. Cyclin D1 (CCND1) is involved in the G1/S transition of the cell cycle by activating Cdk4 and Cdk6 and inhibiting the retinoblastoma protein. Overexpression of cyclinD1 has been associated with the development of various tumors. CyclinD1 and CD10 are useful in the differential and confirmation of mantle cell lymphoma.
CD10 and Cyclin D1 cocktail (RTU Manual), 6ml, AC561-5M, cena 8.793 Kč
CD10 and Cyclin D1 cocktail (RTU Automated), 10ml, AC561-10M, cena 16.023 Kč
Ki67 and Lambda Light Chain Cocktail (K2 and Ployclonal)
CD14 is a glycophosphatidylinositol-anchored protein expressed on the surfaces of monocytes and plymorphonuclear leukocytes. It acts as a co-receptor for the detection of bacterial lipopolysaccharide (LPS). CD14 cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial LPS. It acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. CD14 is expressed strongly on peripheral blood monocytes and macrophages, and weakly on the surface of granulocytes.
Ki67 and Lambda Light Chain cocktail (RTU Manual), 6ml, AC562-5M, cena 5.910 Kč
Ki67 and Lambda Light Chain cocktail (RTU Automated), 10ml, AC562-10M, cena 9.636 Kč
TTF and Cytokeratin 5/6 Cocktail (BGX-397A & EPR1600Y & EPR1602Y Mouse & Rabbit Monoclonal)
Thyroid transcription factor 1 (TTF-1) is a homeodomain-containing transcription factor that regulates the expression of thyroid and lungspecific genes. TTF-1 is detected in small cell carcinomas, neuroendocrine carcinomas, and thyroid carcinomas. As such, TTF-1 can help identify primary pulmonary carcinomas and differentiate it from metastatic carcinomas. Keratins are intermediate filaments found in the cytoskeleton of epithelial cells. Cytokeratin (CK) 5 and 6 are both type II keratins and are associated with the differentiation of simple and stratified epithelial tissue. CK 5/6 has been documented as a useful positive marker for diagnosing malignant mesothelioma. Together, TTF-1 and CK5/6 antibodies form valuable markers to help differentiate between mesotheliomas and pulmonary adenocarcinomas.
TTF and Cytokeratin 5/6 cocktail (RTU Manual), 6ml, AC563-5M, cena 5.910 Kč
TTF and Cytokeratin 5/6 cocktail (RTU Automated), 10ml, AC563-10M, cena 9.636 Kč
